Dr. Allen Khademi is Co-Author of Study Published in New England Journal of Medicine

Allen Khademi, M.D., vice president of medical affairs at Good Shepherd Rehabilitation Network, is the co-author of a multi-national study published recently in the New England Journal of Medicine. The study revealed a significant breakthrough in the treatment of patients in vegetative and minimally conscious states. The study showed that the drug amantadine hydrochloride accelerated the pace of functional recovery during active treatment in patients with post-traumatic disorders of consciousness.

The study, funded by a 5-year, $3 million grant from the National Institute on Disability and Rehabilitation Research, involved 184 patients at 11 clinical trial sites in three countries, including JFK Johnson Rehabilitation Institute in Edison, NJ. Dr. Khademi’s involvement with the study was during his tenure as an attending physician at the JFK Johnson Rehabilitation Institute Center for Head Injuries.

Dr. Khademi, who joined Good Shepherd in 2010, has expertise in traumatic brain injury and stroke rehabilitation. He received his bachelor’s degree in biology from Rutgers University, NJ, and his doctor of medicine degree from Georgetown University School of Medicine, Washington, DC.

JFK Johnson Rehabilitation Institute and MossRehab in Philadelphia served as the lead centers for the international study. Joseph T. Giacino, Ph.D, director of rehabilitation neuropsychology at Spaulding Rehabilitation Hospital and John Whyte, M.D., Ph.D, Director of Moss Rehabilitation Research Institute served as the study’s co-leaders.

The patients involved were receiving inpatient rehabilitation and were in a vegetative or minimally conscious state between four and 16 weeks after traumatic brain injury. During the four week treatment period, recovery was significantly faster among patients who were administered amantadine hydrochloride than those in the placebo group.

“The results of this study provide convincing evidence that it is possible to increase the speed of recovery from severe traumatic brain injury when treatment is initiated within four months of onset. These findings engender optimism for a medical condition that is often viewed as untreatable,” says Dr. Giacino.

The study results pave the way for additional studies of a drug whose therapeutic value was previously undetermined. “Now that we know that amantadine can accelerate neurologic recovery, we need to explore the dose and treatment schedule that provides the greatest and most durable treatment impact,” said study co-leader, John Whyte, M.D., Ph.D, Director of Moss Rehabilitation Research Institute. “Importantly, this study adds to the growing evidence that patients with disorders of consciousness have rehabilitation potential that we are just beginning to tap.”